Publications

2024

Repotrectinib in ROS1 Fusion-Positive Non-Small-Cell Lung Cancer

Contributors from ADDRI: A/Professor Steven Kao

Reference:

Drilon A, Camidge DR, Lin JJ, Kim SW, Solomon BJ, Dziadziuszko R, Besse B, Goto K, de Langen AJ, Wolf J, Lee KH, Popat S, Springfeld C, Nagasaka M, Felip E, Yang N, Velcheti V, Lu S, Kao S, Dooms C, Krebs MG, Yao W, Beg MS, Hu X, Moro-Sibilot D, Cheema P, Stopatschinskaja S, Mehta M, Trone D, Graber A, Sims G, Yuan Y, Cho BC, Trident-1 Investigators. N Engl J Med. 2024 Jan 11;390(2):118-31. doi: 10.1056/NEJMoa2302299. PMID: 38197815

Variations in patterns of prescribing durvalumab in stage III lung cancer: a survey of Australian Medical Oncologists

Contributors from ADDRI: A/Professor Steven Kao

Reference:

Nindra U, Bray V, Karikios D, Shafiei M, Subramaniam S, Ding P, Kao S, Pal A. Oncology. 2024;102(8):732-6. doi: 10.1159/000535855. Epub 2024 Jan 17. PMID: 38232722

First-line chemoimmunotherapy and immunotherapy in patients with non-small cell lung cancer and brain metastases: a registry study

Contributors from ADDRI: A/Professor Steven Kao

Reference:

Brown LJ, Khou V, Brown C, Alexander M, Jayamanne D, Wei J, Gray L, Chan WY, Smith S, Harden S, Mersiades A, Warburton L, Itchins M, Lee JH, Pavlakis N, Clarke SJ, Boyer M, Nagrial A, Hau E, Pires da Silva I, Kao S, Kong BY. Front Oncol. 2024 Feb 7;14:1305720. doi: 10.3389/fonc.2024.1305720. eCollection 2024. PMID: 38406805

Lurbinectedin in small cell lung cancer: real-world experience of a multicentre national early access programme

Contributors from ADDRI: A/Professor Steven Kao

Reference:

Alexander M, Rogers J, Parakh S, Mitchell P, Clay TD, Kao S, Hughes BGM, Itchins M, Kong BY, Pavlakis N, Solomon BJ, John T. Intern Med J. 2024 Jul;54(7):1087-96. doi: 10.1111/imj.16348. Epub 2024 Feb 18. PMID: 38369719

Patient satisfaction with telehealth consultations in medical oncology clinics: A cross-sectional study at a metropolitan centre during the COVID-19 pandemic

Contributors from ADDRI: A/Professor Steven Kao

Reference:

O Parsonson A, Grimison P, Boyer M, Horvath L, Mahon K, Beith J, Kao S, Hui M, Sutherland S, Kumar S, Heller G, McNeil C. J Telemed Telecare. 2024 Feb;30(2):320-6. doi: 10.1177/1357633X211045586. Epub 2021 Oct 16. PMID: 34657513

Influence of EGFR mutation status and PD-L1 expression in stage III unresectable non-small cell lung cancer treated with chemoradiation and consolidation durvalumab

Contributors from ADDRI: A/Professor Steven Kao

Reference:

Nindra U, Shahnam A, Stevens S, Pal A, Nagrial A, Lee J, Yip PY, Adam T, Boyer M, Kao S, Bray V. Asia Pac J Clin Oncol. 2024 Feb;20(1):16-24. doi: 10.1111/ajco.13940. Epub 2023 Feb 28. PMID: 36855021

A Phase II trial of alternating osimertinib and gefitinib therapy in advanced EGFR-T790M positive non-small cell lung cancer: OSCILLATE

Contributors from ADDRI: A/Professor Steven Kao

Reference:

Tan L, Brown C, Mersiades A, Lee CK, John T, Kao S, Newnham G, O'Byrne K, Parakh S, Bray V, Jasas K, Yip S, Wong SQ, Ftouni S, Guinto J, Chandrashekar S, Clarke S, Pavlakis N, Stockler MR, Dawson SJ, Solomon BJ. Nat Commun. 2024 Feb 28;15(1):1823. doi: 10.1038/s41467-024-46008-1. PMID: 38418463

Successful Osimertinib Rechallenge After Relapse Following Adjuvant Osimertinib: A Case Report

Contributors from ADDRI: A/Professor Steven Kao

Reference:

Dwyer LJ, Singhal N, Yu B, Kao S. J Thorac Oncol. 2024 Apr;19(4):650-2. doi: 10.1016/j.jtho.2024.01.001. Epub 2024 Feb 9. PMID: 38340108

Hemophagocytic lymphohistiocytosis (HLH) and cytokine release syndrome (CRS) in a patient with oncogene-addicted metastatic non-small cell lung cancer (NSCLC) following combination chemotherapy-immunotherapy

Contributors from ADDRI: A/Professor Steven Kao

Reference:

Heynemann S, Vanguru V, Adelstein S, Kao S. Asia Pac J Clin Oncol. 2024 Apr;20(2):315-8. doi: 10.1111/ajco.13906. Epub 2022 Dec 23. PMID: 36562695

Brief Report: Real-World Toxicity and Survival of Combination Immunotherapy in Pleural Mesothelioma-RIOMeso

Contributors from ADDRI: A/Professor Steven Kao

Reference:

McNamee N, Harvey C, Gray L, Khoo T, Lingam L, Zhang B, Nindra U, Yip PY, Pal A, Clay T, Arulananda S, Itchins M, Pavlakis N, Kao S, Bowyer S, Chin V, Warburton L, Pires da Silva I, John T, Solomon B, Alexander M, Nagrial A. J Thorac Oncol. 2024 Apr;19(4):636-42. doi: 10.1016/j.jtho.2023.11.014. Epub 2023 Nov 28. PMID: 38036250

Alectinib in Resected ALK-Positive Non-Small-Cell Lung Cancer

Contributors from ADDRI: A/Professor Steven Kao

Reference:

Wu YL, Dziadziuszko R, Ahn JS, Barlesi F, Nishio M, Lee DH, Lee JS, Zhong W, Horinouchi H, Mao W, Hochmair M, de Marinis F, Migliorino MR, Bondarenko I, Lu S, Wang Q, Ochi Lohmann T, Xu T, Cardona A, Ruf T, Noe J, Solomon BJ, ALINA Investigators (Kao S, included). N Engl J Med. 2024 Apr 11;390(14):1265-76. doi: 10.1056/NEJMoa2310532. PMID: 38598794

Treatment selection and real-world analysis of immunotherapy with or without chemotherapy in PD-L1-high metastatic non-small cell lung cancer

Contributors from ADDRI: A/Professor Steven Kao

Reference:

Smith S, Kao S, Boyer M, Franco M, Moore M. Intern Med J. 2024 Aug;54(8):1337-43. doi: 10.1111/imj.16389. Epub 2024 Apr 15. PMID: 38622825

Long-Term Safety and Efficacy of Transcatheter Microwave and Radiofrequency Denervation in a Chronic Ovine Model

Contributors from ADDRI: Dr Virginia James

Reference:

Balaji P, Barry MA, Tran VT, Marschner S, Lu J, Nguyen DM, Mina A, Bandodkar S, Alvarez S, James V, Ronquillo J, Varikatt W, Kovoor P, McEwan A, Thiagalingam A, Thomas SP, Qian PC. Long-Term Safety and Efficacy of Transcatheter Microwave and Radiofrequency Denervation in a Chronic Ovine Model. J Am Heart Assoc. 2024 May 7;13(9):e031795. doi: 10.1161/JAHA.123.031795. Epub 2024 Apr 25. PMID: 38664237.

A novel dye-sensitised solar cell based portable sensor for chemical detection

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Xue Y, Lei B, Feng X, Ye M, Hazelton P, Huang Y, Fan X, Zhu G, Robertson N, Hosseini-Beheshti E, Chen X. A novel dye-sensitised solar cell based portable sensor for chemical detection, Accepted in Sensors and Actuators B: Chemical (IF: 8.4)

Engineered extracellular vesicles expressing ICAM-1: A promising targeted delivery system for T cell modifications

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Shahrabi Farahani M, Hosseini-Beheshti E, Moazzeni SM, Forouzandeh Moghadam M. Engineered extracellular vesicles expressing ICAM-1: A promising targeted delivery system for T cell modifications. Biochim Biophys Acta Gen Subj. 2023 Dec 14:130541. doi: 10.1016/j.bbagen.2023.130541. Online ahead of print

Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches. Welsh JA, Goberdhan DCI, Lorraine O'Driscoll, MISEV consortium, Witwer KW. JEV, 2024 (IF: 17.37)

Real world efficacy and toxicity of consolidation durvalumab following chemoradiotherapy in older Australian patients with unresectable stage III non-small cell lung cancer

Contributors from ADDRI: A/Professor Anthony Linton A/Professor Steven Kao

Reference:

Stevens S, Nindra U, Shahnam A, Wei J, Bray V, Pal Abhijit, Yip PY, Linton A, et al. Real world efficacy and toxicity of consolidation durvalumab following chemoradiotherapy in older Australian patients with unresectable stage III non-small cell lung cancer. Journal of Geriatric Oncology. 2024. 15 101705

2023

LOREALAUS: LOrlatinib REAL-World AUStralian Experience in Advanced ALK-Rearranged NSCLC

Contributors from ADDRI: A/Professor Steven Kao

Reference:

Alexander M, Wei J, Parakh S, John T, Kao S, Nagrial A, Bowyer S, Warburton L, Moore M, Hughes BGM, Clay TD, Pavlakis N, Solomon BJ, Itchins M. JTO Clin Res Rep. 2023 Feb 26;4(4):100490. doi: 10.1016/j.jtocrr.2023.100490. eCollection 2023 Apr. PMID: 37077199

Accurate isolation and detection of circulating tumor cells using enrichment-free multiparametric high resolution imaging

Contributors from ADDRI: A/Professor Steven Kao

Reference:

Yeo D, Kao S, Gupta R, Wahlroos S, Bastian A, Strauss H, Klemm V, Shrestha P, Ramirez AB, Costandy L, Huston R, Gardner BS, Grimison P, Clark JR, Rasko JEJ. Front Oncol. 2023 Mar 27;13:1141228. doi: 10.3389/fonc.2023.1141228. eCollection 2023. PMID: 37051527

Leptospermum extract (QV0) suppresses pleural mesothelioma tumor growth in vitro and in vivo by mitochondrial dysfunction associated apoptosis

Contributors from ADDRI: Dr Peter (Huaikai) Shi Ling Zhuang Dr Ben Johnson A/Professor Steven Kao

Reference:

Shi H, Zhang L, Yu TK, Zhuang L, Ke H, Johnson B, Rath E, Lee K, Klebe S, Kao S, Qin KL, Pham HNT, Vuong Q, Cheng YY. Front Oncol. 2023 Jul 5;13:1162027. doi: 10.3389/fonc.2023.1162027. eCollection 2023. PMID: 37476375

AdvanTIG-105: a phase I dose escalation study of the anti-TIGIT monoclonal antibody ociperlimab in combination with tislelizumab in patients with advanced solid tumors

Contributors from ADDRI: A/Professor Steven Kao

Reference:

Frentzas S, Kao S, Gao R, Zheng H, Rizwan A, Budha N, de la Hoz Pedroza L, Tan W, Meniawy T. J Immunother Cancer. 2023 Oct;11(10):e005829. doi: 10.1136/jitc-2022-005829. PMID: 37857528

PEMMELA: a promising regimen at the expense of toxicity

Contributors from ADDRI: A/Professor Steven Kao

Reference:

Smith S, Kao S. Lancet Oncol. 2023 Nov;24(11):1161-2. doi: 10.1016/S1470-2045(23)00512-0. Epub 2023 Oct 13. PMID: 37844596

A tailored approach to horizon scanning for cancer medicines

Contributors from ADDRI: A/Professor Steven Kao

Reference:

Soon JA, To YH, Alexander M, Trapani K, Ascierto PA, Athan S, Brown MP, Burge M, Haydon A, Hughes B, Itchins M, John T, Kao S, Koopman M, Li BT, Long GV, Loree JM, Markman B, Meniawy TM, Menzies AM, Nott L, Pavlakis N, Petrella TM, Popat S, Tie J, Xu W, Yip D, Zalcberg J, Solomon BJ, Gibbs P, McArthur GA, Franchini F, IJzerman M. J Cancer Policy. 2023 Dec;38:100441. doi: 10.1016/j.jcpo.2023.100441. Epub 2023 Nov 20. PMID: 38008488

Re-re-biopsy? How much tumor is enough in the era of precision oncology?

Contributors from ADDRI: A/Professor Steven Kao

Reference:

Smith S, Boyer M, Kao S. Asia Pac J Clin Oncol. 2023 Dec;19(6):581-4. doi: 10.1111/ajco.14030. Epub 2023 Oct 2. PMID: 37784252

HERTHENA-Lung01, a Phase II Trial of Patritumab Deruxtecan (HER3-DXd) in Epidermal Growth Factor Receptor-Mutated Non-Small-Cell Lung Cancer After Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Therapy and Platinum-Based Chemotherapy

Contributors from ADDRI: A/Professor Steven Kao

Reference:

Yu HA, Goto Y, Hayashi H, Felip E, Chih-Hsin Yang J, Reck M, Yoh K, Lee SH, Paz-Ares L, Besse B, Bironzo P, Kim DW, Johnson ML, Wu YL, John T, Kao S, Kozuki T, Massarelli E, Patel J, Smit E, Reckamp KL, Dong Q, Shrestha P, Fan PD, Patel P, Sporchia A, Sternberg DW, Sellami D, Janne PA. J Clin Oncol. 2023 Dec 10;41(35):5363-75. doi: 10.1200/JCO.23.01476. Epub 2023 Sep 10. PMID: 37689979

Skin 11β-hydroxysteroid dehydrogenase type 1 enzyme expression regulates burn wound healing and can be targeted to modify scar characteristics

Contributors from ADDRI: Dr Peter (Huaikai) Shi

Reference:

Tsai KH, Shi H, Parungao RJ, Naficy S, Ding X, Ding X, Hew JJ, Wang X, Chrzanowski W, Lavery GG, Li Z, Issler-Fisher AC, Chen J, Tan Q, Maitz PK, Cooper MS, Wang Y. Skin 11β-hydroxysteroid dehydrogenase type 1 enzyme expression regulates burn wound healing and can be targeted to modify scar characteristics. Burns Trauma. 2023 Jan 20;11:tkac052. doi: 10.1093/burnst/tkac052. eCollection 2023. PMID: 36694861

Advanced pathophysiology mimicking lung models for accelerated drug discovery

Contributors from ADDRI: Dr Peter (Huaikai) Shi

Reference:

Phan TH, Shi H, Denes CE, Cole AJ, Wang Y, Cheng YY, Hesselson D, Roelofs SH, Neely GG, Jang JH, Chrzanowski W. Advanced pathophysiology mimicking lung models for accelerated drug discovery. Biomater Res. 2023 Apr 26;27(1):35. doi: 10.1186/s40824-023-00366-x. PMID: 37098610

A structural analysis of the nsp9 protein from the coronavirus MERS CoV reveals a conserved RNA binding interface

Contributors from ADDRI: David Baker

Reference:

A structural analysis of the nsp9 protein from the coronavirus MERS CoV reveals a conserved RNA binding interface https://doi.org/10.1002/prot.26630

Extracellular vesicles from biological fluids as potential markers in castration resistant prostate cancer

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Choi W, Sánchez C, Li JJ, Dinarvand M, Adomat H, Ghaffari M, Khoja L, Vafaee F, Joshua A, Chi KN, Tomlinson Guns ES, Hosseini-Beheshti E. Extracellular vesicles from biological fluids as potential markers in castration resistant prostate cancer. J Cancer Res Clin Oncol. 2022 Oct 12. (IF: 4.55).

ImmunoInertial microfluidics: A novel strategy for isolation of small EV subpopulations

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Razavi Bazaz S, Zhand S, Salomon R, Ortega DG, Hosseini-Beheshti E, Jin D, Warkiani M. Immuno Inertial microfluidics: a novel strategy for exosome subpopulation separation. Micromachines 2023, 14, 751. (IF:3.52)

Small and large extracellular vesicles derived from pleural mesothelioma cell lines offer biomarker potential

Contributors from ADDRI: A/Professor Steven Kao Dr Elham Hosseini Beheshti

Reference:

Ahmadzada T, Vijayan A, Vafaee F, Reid G, Kao S, Grau GER, Clark S, Hosseini-Beheshti E. Small and large extracellular vesicles derived from pleural mesothelioma cell lines offer biomarker potential Cancers (Basel). 2023 Apr 18;15(8):2364. (IF:6.57)

Immunomodulatory potential of human clonal mesenchymal stem cells and their extracellular vesicle subpopulations in an inflammatory-mediated diabetic Rhesus monkey model

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Assar Kashani S, Navabi R, Amini A, Hajinasrollah M, Jenab Y , Rabbani Sh, Nazari A, Pakzad M, Moazenchi M, Jafari Atrabi M, Samsonchi Z, Hezavehei M, Hosseini-Beheshti E, Shekari F, Hajizadeh-Saffar E, Baharvand H. Immunomodulatory Potential of Human Clonal Mesenchymal Stem Cells and 2 their Extracellular Vesicle Subpopulations in an Inflammatory-Mediated 3 Diabetic Rhesus Monkey Model, accepted in Life Sciences. (IF: 6.78)

Lidocaine for Neuropathic Cancer Pain (LiCPain): study protocol for a mixed methods pilot study

Contributors from ADDRI: A/Professor Anthony Linton

Reference:

Lee J, Currow D, Phillips JL, McLachlan A, Linton A, et al. Lidocaine for Neuropathic Cancer Pain (LiCPain): study protocol for a mixed methods pilot study. BMJ Open. 2023 Feb 21;13(2):e066125.

High mesothelin expression by immunohistochemistry predicts improved survival in pleural mesothelioma

Contributors from ADDRI: A/Professor Anthony Linton A/Professor Steven Kao

Reference:

Chu GJ, Linton A, Kao SC, Klebe S, et al. High mesothelin expression by immunohistochemistry predicts improved survival in pleural mesothelioma. Histopathology. 2023. Accepted for publication.

2022

An update on emerging therapeutic options for malignant pleural mesothelioma

Contributors from ADDRI: A/Professor Steven Kao

Reference:

Davis A, Ke H, Kao S, Pavlakis N. Lung Cancer (Auckl). 2022 Mar 2;13:1-12. doi: 10.2147/LCTT.S288535. PMID: 35264891

The emerging role of the lung microbiome and its importance in non-small cell lung cancer diagnosis and treatment

Contributors from ADDRI: A/Professor Steven Kao

Reference:

McLean AEB, Kao SC, Barnes DJ, Wong KKH, Scolyer RA, Cooper WA, Kohonen-Corish MRJ. Lung Cancer. 2022 Mar;165:124-32. doi: 10.1016/j.lungcan.2022.01.011. Epub 2022 Jan 20. PMID: 35123155

Corrigendum to “The emerging role of the lung microbiome and its importance in non-small cell lung cancer diagnosis and treatment” [Lung Cancer 165C (2022) 124-132]

Contributors from ADDRI: A/Professor Steven Kao

Reference:

McLean AEB, Kao SC, Barnes DJ, Wong KKH, Scolyer RA, Cooper WA, Kohonen-Corish MRJ. Lung Cancer. 2022 Apr;166:252. doi: 10.1016/j.lungcan.2022.02.011. Epub 2022 Mar 9. PMID: 35279297

Pembrolizumab for previously treated advanced anal squamous cell carcinoma: results from the non-randomised, multicohort, multicentre, phase 2 KEYNOTE-158 study

Contributors from ADDRI: A/Professor Steven Kao

Reference:

Marabelle A, Cassier PA, Fakih M, Kao S, Nielsen D, Italiano A, Guren TK, van Dongen MGJ, Spencer K, Bariani GM, Ascierto PA, Santoro A, Shah M, Asselah J, Iqbal S, Takahashi S, Piha-Paul SA, Ott PA, Chatterjee A, Jin F, Norwood K, Delord JP. Lancet Gastroenterol Hepatol. 2022 May;7(5):446-54. doi: 10.1016/S2468-1253(21)00382-4. Epub 2022 Feb 1. PMID: 35114169

Dying of mesothelioma: A qualitative exploration of caregiver experiences

Contributors from ADDRI: A/Professor Steven Kao

Reference:

Lee JT, Mittal DL, Warby A, Kao S, Dhillon HM, Vardy JL. Eur J Cancer Care (Engl). 2022 Sep;31(5):e13627. doi: 10.1111/ecc.13627. Epub 2022 Jun 20. PMID: 35723508

Asbestos-related lung cancer: Clinical characteristics and survival outcomes in an Australian cohort seeking workers compensation

Contributors from ADDRI: A/Professor Steven Kao

Reference:

Hyland RA, Chrzanowska A, Hannaford-Turner K, Davis A, Ke H, Bradbury L, Nagrial A, McCaughan B, Hui R, van Zandwijk N, Takahashi K, Kao SC. Asia Pac J Clin Oncol. 2022 Oct;18(5):e448-e55. doi: 10.1111/ajco.13664. Epub 2022 Jan 31. PMID: 35100476

A case of steroid responsive nivolumab induced cholangitis

Contributors from ADDRI: A/Professor Steven Kao

Reference:

Kynaston A, Liu K, Davis A, Kao S, McKenzie C. Pathology. 2022 Oct;54(6):820-3. doi: 10.1016/j.pathol.2021.11.009. Epub 2022 Feb 10. PMID: 35153072

Elevated neutrophil-to-lymphocyte ratio (NLR) is associated with poorer progression-free survival in unresectable stage III NSCLC treated with consolidation durvalumab

Contributors from ADDRI: A/Professor Steven Kao

Reference:

Nindra U, Shahnam A, Stevens S, Pal A, Nagrial A, Lee J, Yip PY, Adam T, Boyer M, Kao S, Bray V. Thorac Cancer. 2022 Nov;13(21):3058-62. doi: 10.1111/1759-7714.14646. Epub 2022 Sep 16. PMID: 36111516

A multi-center real-world experience of IMpower150 in oncogene driven tumors and CNS metastases

Contributors from ADDRI: A/Professor Steven Kao

Reference:

Itchins M, Ainsworth H, Alexander M, Dean S, Dharmaraj D, Pavlakis N, Clarke SJ, Brown C, Torres J, Saqib A, Ladwa R, O'Byrne K, Moore M, Yip PY, Solomon B, John T, Kao S, Mitchell P, Parakh S. Clin Lung Cancer. 2022 Dec;23(8):702-8. doi: 10.1016/j.cllc.2022.07.016. Epub 2022 Aug 7. PMID: 36030187

Squamous cell carcinoma differentiation at progression as a resistance mechanism in metastatic non-small cell lung carcinoma harbouring a targetable mutation

Contributors from ADDRI: A/Professor Steven Kao

Reference:

Heynemann S, Prosser N, Lee J, Mahar A, Anderson L, Kao S, Cooper WA. Pathology. 2022 Dec;54(7):935-8. doi: 10.1016/j.pathol.2022.02.004. Epub 2022 May 12. PMID: 35570027

Exploring MicroRNA and exosome involvement in malignant pleural mesothelioma drug response

Contributors from ADDRI: Dr Ben Johnson Ling Zhuang Dr Peter (Huaikai) Shi A/Professor Steven Kao

Reference:

Johnson B, Zhuang L, Rath E, Yuen ML, Cheng NC, Shi H, Kao S, Reid G, Cheng YY. Exploring MicroRNA and exosome involvement in malignant pleural mesothelioma drug response. Cancers (Basel). 2022 Sep 30;14(19):4784. doi: 10.3390/cancers14194784. PMID: 36230710

Controlled dual release of dihydrotestosterone and flutamide from polycaprolactone (PCL) electrospun scaffold accelerates burn wound healing

Contributors from ADDRI: Dr Peter (Huaikai) Shi

Reference:

Shi H, Tsai KH, Ma D, Wang X, Desai R, Parungao RJ, Hunt NJ, Cheng YY, Zhang H, Xu Y, Simanainen U, Tan Q, Cooper MS, Handelsman DJ, Maitz PK, Wang Y. Controlled dual release of dihydrotestosterone and flutamide from polycaprolactone (PCL) electrospun scaffold accelerates burn wound healing. FASEB J. 2022 May;36(5):e22310. doi: 10.1096/fj.202101803R. PMID: 35394674

Exploring the role of extracellular vesicles and their protein cargo in lung cancer metastasis: a review

Contributors from ADDRI: A/Professor Steven Kao Dr Elham Hosseini Beheshti

Reference:

Whittle K, Kao S, Clarke S, Grau GER, Hosseini-Beheshti E. Exploring the role of extracellular vesicles and their protein cargo in lung cancer metastasis: a review. Crit Rev Oncol Hematol 2022 Jan 20;103603. (IF: 6.31)

Chloroquine treatment induces secretion of autophagy-related proteins and inclusion of Atg8-family proteins in distinct extracellular vesicle populations

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Xu J, Yang KC, Colborne S, Hosseini-Beheshti E, Guns E, Morin G, Gorski SM. Chloroquine treatment induces secretion of autophagy-related proteins and inclusion of Atg8-family proteins in distinct extracellular vesicle populations. Autophagy. 2022 Feb 7. IF: 16.02

Extracellular Vesicles: Interplay with the Extracellular Matrix and Modulated Cell Responses

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Al Halawani, A.; Mithieux, S.M.; Yeo, G.C.; Hosseini-Beheshti, E.; Weiss, A.S. Extracellular Vesicles: Interplay with the Extracellular Matrix and Modulated Cell Responses. Int. J. Mol. Sci. 2022, 23, 3389. (IF: 5.92)

Bacterial extracellular vesicles and their novel applications in health

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Hosseini Giv N, Bass A, Hicks C, El-Omar E, El-Assad F, Hosseini-Beheshti E. Bacterial extracellular vesicles and their novel applications in health. Front Cell Infect Microbiol. 2022 Nov 11;12:962216. (IF: 5.3).

Investigation of Plasma-Derived Lipidome Profiles in Experimental Cerebral Malaria in a Mouse Model Study

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Batarseh A, Vafaee F, Hosseini-Beheshti E, Chen A, Cohen A, Juillard A, Hunt NH, Mariani M, Mitchel T and Grau GER. Lipidomics profiles of plasma microvesicles differ in experimental cerebral malaria, compared to malaria without neurological complications. Int J Mol Sci. 2022 Dec 28;24(1):501. (IF:6.21)

GUIDE: a randomised non-comparative phase II trial of biomarker-driven intermittent docetaxel versus standard-of-care docetaxel in metastatic castration-resistant prostate cancer (clinical trial protocol)

Contributors from ADDRI: A/Professor Anthony Linton

Reference:

Conduit C, Mak B ,Lulio JD, Burder R, Linton A, et al. GUIDE: a randomised non-comparative phase II trial of biomarker-driven intermittent docetaxel versus standard-of-care docetaxel in metastatic castration-resistant prostate cancer (clinical trial protocol). Ther Adv Med Oncol 2022. Apr 18:14.

The Minimum Standard of Care for Managing Malignant Pleural Mesothelioma in Developing Nations within the Asia-Pacific Region

Contributors from ADDRI: A/Professor Steven Kao A/Professor Anthony Linton

Reference:

Ke H, Kao S, Lee K, Takahashi K, Goh H, Linton A. The Minimum Standard of Care for Managing Malignant Pleural Mesothelioma in Developing Nations within the Asia-Pacific Region. Asia Pac J Clin Oncol. 2022. June;18(3): 177-190

3-Dimensional mesothelioma spheroids provide closer to natural pathphysiological tumour microenvironment for drug response studies

Contributors from ADDRI: Dr Peter (Huaikai) Shi A/Professor Anthony Linton A/Professor Steven Kao

Reference:

Huaikai S, Rath E, Sarun K, Lin R, Linton A, et al. 3-Dimensional mesothelioma spheroids provide closer to natural pathphysiological tumour microenvironment for drug response studies. Frontiers in Oncology. 2022. Aug 26;12:973576

2021

Malignant peritoneal mesothelioma with EWSR1-ATF1 fusion: a case report

Contributors from ADDRI: A/Professor Steven Kao

Reference:

Ke H, Gill AJ, McKenzie C, Kench JG, Chan RCF, Pavlakis N, Fulham M, Koh C, Kao S. JTO Clin Res Rep. 2021 Oct 11;2(11):100236. doi: 10.1016/j.jtocrr.2021.100236. eCollection 2021 Nov. PMID: 34766064

EGFR Exon 20 insertion mutations: clinicopathological characteristics and treatment outcomes in advanced non-small cell lung cancer

Contributors from ADDRI: A/Professor Steven Kao

Reference:

Leal JL, Alexander M, Itchins M, Wright GM, Kao S, Hughes BGM, Pavlakis N, Clarke S, Gill AJ, Ainsworth H, Solomon B, John T. Clin Lung Cancer. 2021 Nov;22(6):e859-e69. doi: 10.1016/j.cllc.2021.04.009. Epub 2021 May 16. PMID: 34127383

Preclinical models and resources to facilitate basic science research on malignant mesothelioma–a review

Contributors from ADDRI: Dr Ben Johnson

Reference:

Johnson BW, Takahashi K, Cheng YY. Front Oncol. 2021 Nov 11;11:748444. doi: 10.3389/fonc.2021.748444. eCollection 2021. PMID: 34900693

The role of E-cadherin and microRNA on FAK inhibitor response in malignant pleural mesothelioma (MPM)

Contributors from ADDRI: Ling Zhuang Dr Ben Johnson A/Professor Steven Kao A/Professor Anthony Linton

Reference:

Yuen ML, Zhuang L, Rath EM, Yu T, Johnson B, Sarun KH, Wang Y, Kao S, Linton A, Clarke CJ, McCaughan BC, Takahashi K, Lee K, Cheng YY. Int J Mol Sci. 2021 Sep 23;22(19):10225. doi: 10.3390/ijms221910225. PMID: 34638565

The contradictory role of androgens in cutaneous and major burn wound healing

Contributors from ADDRI: Dr Peter (Huaikai) Shi

Reference:

Shi H, Cheer K, Simanainen U, Lesmana B, Ma D, Hew JJ, Parungao RJ, Li Z, Cooper MS, Handelsman DJ, Maitz PK, Wang Y. Burns Trauma. 2021 Apr 20;9:tkaa046. doi: 10.1093/burnst/tkaa046. eCollection 2021 Jan. PMID: 33928173

Extracellular Vesicles from Mesenchymal Stromal Cells for the Treatment of Inflammation-Related Conditions

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Ryan ST, Hosseini-Beheshti E, Afrose D, Ding X, Xia B, Grau GE, Little CB, McClements L, Li JJ. Extracellular Vesicles from Mesenchymal Stromal Cells for the Treatment of Inflammation-Related Conditions. Int J Mol Sci. 2021 Mar 16;22(6):3023.doi: 10.3390/ijms22063023. (IF: 5.92)

Application of extracellular vesicles in the diagnosis and treatment of prostate cancer: implications for clinical practice

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Oey O, Ghaffar M, Li J, Hosseini-Beheshti E. Application of extracellular vesicles in the diagnosis and treatment of prostate cancer: implications for clinical practice. Crit Rev Oncol Hematol 2021 Oct 13;103495. (IF: 6.31)

Evaluation of a Mainstream Model of Genetic Testing for Men with Prostate Cancer

Contributors from ADDRI: A/Professor Anthony Linton

Reference:

Scheinberg T, Goodwin A, Ip E, Linton A, et al. Evaluation of a Mainstream Model of Genetic Testing for Men with Prostate Cancer. JCO Oncol Pract. 2021 Feb:17(2):e204-e216)

2020

The Use of Immunohistochemistry, Fluorescence in situ Hybridization, and Emerging Epigenetic Markers in the Diagnosis of Malignant Pleural Mesothelioma (MPM): A Review

Contributors from ADDRI: Dr Ben Johnson

Reference:

Rozitis E, Johnson B, Cheng YY, Lee K. Front Oncol. 2020 Sep 9;10:1742. doi: doi.org/10.3389/fonc.2020.01742. eCollection 2020. PMID: 33014860

Extracellular vesicles as biomarkers in Malignant Pleural Mesothelioma: A review

Contributors from ADDRI: Dr Elham Hosseini Beheshti A/Professor Steven Kao

Reference:

Ahmadzada T, Kao S, Reid G, Clarke S, Grau GE, Hosseini-Beheshti E. Extracellular vesicles as biomarkers in Malignant Pleural Mesothelioma: A review. Critical Reviews in Oncology/Hematology. 2020;150:102949. (IF: 6.31)

Retrospective Evaluation of the Use of Pembrolizumab in Malignant Mesothelioma in a Real-World Australian Population

Contributors from ADDRI: Dr Elham Hosseini Beheshti A/Professor Steven Kao

Reference:

Ahmadzada T, Cooper W, Holmes M, Westman H, Gill1 A, Nordman I, Yip PY, Pal A, Zielinski R, Pavlakis N, Nagrial A, Brungs D, Karikos D, Aleksova V, Burns J, Asher R, Grau GE , Hosseini-Beheshti E, Reid G, Clarke S, Kao S. Retrospective evaluation of the use of pembrolizumab in malignant pleural mesothelioma. JTOCRR 100075. (IF=15.61)

The Current Understanding of Asbestos-Induced Epigenetic Changes Associated with Lung Cancer

Contributors from ADDRI: A/Professor Anthony Linton

Reference:

Cheng YY, Rath EM, Linton A, et al. The Current Understanding of Asbestos-Induced Epigenetic Changes Associated with Lung Cancer. Lung Cancer. 2020 Jan 8;11:1-11. doi: 10.2147/LCTT.S186843. eCollection 2020.

CDKN2A and MTAP Are Useful Biomarkers Detectable by Droplet Digital PCR in Malignant Pleural Mesothelioma: A Potential Alternative Method in Diagnosis Compared to Fluorescence In Situ Hybridisation

Contributors from ADDRI: A/Professor Anthony Linton A/Professor Steven Kao Dr Ben Johnson Ling Zhuang

Reference:

Cheng YY, Yuen ML, Rath EM, Linton A, et al. CDKN2A and MTAP Are Useful Biomarkers Detectable by Droplet Digital PCR in Malignant Pleural Mesothelioma: A Potential Alternative Method in Diagnosis Compared to Fluorescnece In Situ Hybridisation. Front Oncol. 2020. Nov 13;10:579327

2019

Transvascular Pacing of aorticorenal ganglia provides testable procedural endpoint for renal artery denervation

Contributors from ADDRI: Dr Virginia James

Reference:

Qian. P, Barry. M. Lu, Pouliopoulos, J, Mina. A, Bandodkar. S, James. V, Ronquillo. J. Thomas, S. et al. ▪ Transvascular Pacing of aorticorenal ganglia provides testable procedural endpoint for renal artery denervation. JACC: Cardiovascular Interventions 2019.

Transcatheter microwave ablation can deliver deep and circumferential perivascular nerve injury without significant arterial injury to provide effective renal denervation

Contributors from ADDRI: Dr Virginia James

Reference:

Qian. P, Barry. M. Lu, Al Raisi. S, Mina. A, Ryan. J, Bandodkar. S, James. V, Chong. J, Thomas, S. et al. ▪ Transcatheter microwave ablation can deliver deep and circumferential perivascular nerve injury without significant arterial injury to provide effective renal denervation. Journal of Hypertension 2018.

Interplay of Extracellular Vesicles and Other Players in Cerebral Malaria Pathogenesis

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Debs S, Cohen A, Hosseini-Beheshti E, Chimini G, Hunt NH, and Grau G. Interplay of Extracellular Vesicles and Other Players in Cerebral Malaria Pathogenesis. Biochim Biophys Acta Gen Subj. 2018 Oct 17;1863(2):325-331. (IF=3.77)

Extracellular vesicles and microvascular pathology: Decoding the active dialogue.

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Hosseini-Beheshti E, Grau GER. Extracellular vesicles and microvascular pathology: Decoding the active dialogue. Microcirculation. 2019;26:e12485. (IF=2.63)

Extracellular Fatty Acids Are the Major Contributor to Lipid Synthesis in Prostate Cancer

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Balaban S, Nassar ZD, Zhang AY, Hosseini-Beheshti E, Centenera MM, Schreuder M, Lin HM, Aishah A, Varney B, Liu-Fu F, Lee LS, Nagarajan SR, Shearer RF, Hardie RA, Raftopulos NL, Kakani MS, Saunders DN, Holst J, Horvath LG, Butler LM, Hoy AJ. Extracellular Fatty Acids Are the Major Contributor to Lipid Synthesis in Prostate Cancer. Mol Cancer Res. 2019 Jan 15. (IF=5.85)

Stem Cell-Derived Extracellular Vesicles for Treating Joint Injury and Osteoarthritis.

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Li JJ, Hosseini-Beheshti E, Grau GE, Zreiqat H, Little CB. Stem Cell-Derived Extracellular Vesicles for Treating Joint Injury and Osteoarthritis. Nanomaterials (Basel). 2019 Feb 14;9(2). pii: E261. (IF=5.08)

Host- and microbiota-derived extracellular vesicles, immune function and disease development

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Macia L, Nanan R, Hosseini-Beheshti E, Grau GE. Host- and microbiota-derived extracellular vesicles, immune function and disease development. Int. J. Mol. Sci. 2020, 21(1), 107. IF: 5.92

High BIN1 expression has a favourable prognosis in malignant pleural mesothelioma and is associated with tumor infiltrating lymphocytes

Contributors from ADDRI: A/Professor Anthony Linton A/Professor Steven Kao

Reference:

Ahmadzada T, Lee K, Clarke C, Cooper WA, Linton A, et al. High BIN1 expression has a favourable prognosis in malignant pleural mesothelioma and is associated with tumor infiltrating lymphocytes. Lung Cancer. 2019 Apr; 130:35-41.

Patterns of care and survival of older patients with malignant pleural mesothelioma

Contributors from ADDRI: A/Professor Anthony Linton A/Professor Steven Kao

Reference:

Linton A, Blinman P, Kao S, van Zandwijk N. Patterns of care and survival of older patients with malignant pleural mesothelioma. Jour Geriatric Oncology. 2019 July; 10(4):573-576.

2018

The interactions of novel mononuclear platinum-based complexes with DNA

Contributors from ADDRI: Dr Ben Johnson

Reference:

Johnson BW, Burgess MW, Murray V, Aldrich-Wright JR, Temple MD. BMC Cancer. 2018 Dec 22;18(1):1284. doi: 10.1186/s12885-018-5194-8. PMID: 30577821

Extracellular vesicles as mediators of immunopathology in infectious diseases.

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Hosseini-Beheshti E, Grau G. Extracellular vesicles as mediators of immunopathology in infectious diseases. Immunol Cell Biol. 2018 Mar 25. (IF=5.13)

Dysregulated Expression of the MicroRNA miR-137 and Its Target YBX1 Contribute to the Invasive Characteristics of Malignant Pleural Mesothelioma

Contributors from ADDRI: A/Professor Anthony Linton A/Professor Steven Kao

Reference:

Johnson TG, Schelch K, Cheng YY, Williams M, Sarun KH, Kirschner MB, Kao S, Linton A, et al. Dysregulated Expression of the MicroRNA miR-137 and Its Target YBX1 Contribute to the Invasive Characteristics of Malignant Pleural Mesothelioma. J Thorac Oncol. 2018 Feb;13(2):258- 272. doi: 10.1016/j.jtho.2017.10.016. Epub 2017 Nov 4.

2017

Role of hepatic Annexin A6 in fatty acid -induced lipid droplet formation

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Cairns R, Alvarez-Guaita A, Martínez-Saludes I, Wason SJ, Hhan J, Nagarajan SR, Hosseini-Beheshti E, Monastyrskaya K, Hoy AJ, Buechler C, Enrich C, Rentero C, Role of hepatic Annexin A6 in fatty acid -induced lipid droplet formation. Exp Cell Res. 2017 Jul 14. pii: S0014-4827(17)30368-3. (IF=3.91)

Geographic and socioeconomic factors in patients with malignant pleural mesothelioma in New South Wales and their impact upon clinical outcomes

Contributors from ADDRI: A/Professor Anthony Linton A/Professor Steven Kao

Reference:

Linton A, Soeberg M, Broome R, Kao S, van Zandwijk N. Geographic and socioeconomic factors in patients with malignant pleural mesothelioma in New South Wales and their impact upon clinical outcomes. Respirology. 2017 July; 22(5): 978-985

Tumour suppressor microRNAs contribute to the regulation of PD-L1 expression in malignant pleural mesothelioma

Contributors from ADDRI: A/Professor Anthony Linton A/Professor Steven Kao

Reference:

Kao SC, Cheng YY, Williams M, Kirschner MB, Linton A, et al. Tumour suppressor microRNAs contribute to the regulation of PD-L1 expression in malignant pleural mesothelioma. Journal Thoracic Oncology. 2017 Jun 16. pii: S1556-0864(17)30460-4.

Safety and activity of microRNA-loaded minicells in patients with recurrent malignant pleural mesothelioma: a first-in-man, phase 1, open-label, dose-escalation study

Contributors from ADDRI: A/Professor Anthony Linton A/Professor Steven Kao

Reference:

van Zandwijk N, Pavlakis N, Kao SC, Linton A, et al. Safety and activity of microRNA-loaded minicells in patients with recurrent malignant pleural mesothelioma: a first-in-man, phase 1, open-label, dose-escalation study. Lancet Oncology. 2017 Oct;18(10):1386-1396. doi: 10.1016/S1470-2045(17)30621-6. Epub 2017 Sep 1

2016

Characterisation of the DNA sequence specificity, cellular toxicity and cross-linking properties of novel bispyridine-based dinuclear platinum complexes

Contributors from ADDRI: Dr Ben Johnson

Reference:

Johnson BW, Murray V, Temple MD. BMC Cancer. 2016 May 25;16:333. doi: 10.1186/s12885-016-2368-0. PMID: 27225032

Exosomes Confer Pro-survival Signals to Alter the Phenotype of Prostate Cells in Their Surrounding Environment

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Hosseini-Beheshti E, Choi W, Weiswald LB, Kharmate G, Ghaffari M, Roshan-Moniri M, Hassona MD, Chan L, Chin MY, Rennie PS, Tai IT, Fazli L, Guns (Tomlinson) ES. Exosomes Confer Pro-survival Signals to Alter the Phenotype of Prostate Cells in Their Surrounding Environment. Oncotarget. 2016 Mar 22;7(12):14639-58. (IF=5.20)

Epidermal Growth Factor in Prostate Cancer derived Exosomes

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Kharmate G, Hosseini-Beheshti E, Caradec J, Chin MY Guns (Tomlinson) ES. Epidermal Growth Factor in Prostate Cancer derived Exosomes. PLoS One. 2016 May 6;11(5):e0154967. (IF=3.24)

2015

Initial interactions of herpes simplex virus with human skin dendritic cells

Contributors from ADDRI: Dr Virginia James

Reference:

Min. K, Truong N. R, V. James, Cunningham. A. LB1.5 Initial interactions of herpes simplex virus with human skin dendritic cells. Sexually Transmitted Infections (BMJ) 2015

Regulation of Local Steroidogenesis in the Brain and in Prostate Cancer: Lessons learned from interdisciplinary collaboration.

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Fokidis HB, Adomat H, Kharmate G, Hosseini-Beheshti E, Guns E., Soma KK. Regulation of Local Steroidogenesis in the Brain and in Prostate Cancer: Lessons learned from interdisciplinary collaboration. Front Neuroendocrinol. 2014 Sep 16. pii: S0091-3022(14)00077-6. (IF=8.61)

Large Oncosomes Contain Distinct Protein Cargo and Represent a Separate Functional Class of Tumor-Derived Extracellular Vesicles.

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Minciacchi V, You S, Spinelli C, Morley S, Zandian M, Aspuria PJ, Cavallini L, Ciardiello C, Sobreiro MR, Morello M, Kharmate G, Jang S, Kim DK, Hosseini-Beheshti E, Guns E, Gleave M, Gho Y, Mathivanan S, Yang W, Freeman M, Di Vizio D. Large Oncosomes Contain Distinct Protein Cargo and Represent a Separate Functional Class of Tumor-Derived Extracellular Vesicles. Oncotarget. 2015 May 10;6(13):11327-41. (IF=5.01)

MiR-score: a novel 6-microRNA signature that predicts survival outcomes in patients with malignant pleural mesothelioma

Contributors from ADDRI: A/Professor Anthony Linton A/Professor Steven Kao

Reference:

Kirschner MB, Cheng YY, Armstrong NJ, Lin RC, Kao SC, Linton A, Klebe S, McCaughan BC, van Zandwijk N, Reid G. MiR-score: a novel 6-microRNA signature that predicts survival outcomes in patients with malignant pleural mesothelioma. Molecular Oncology. 2015; 9(3): 715-26.

miR-193a-3p is a potential tumor suppressor in malignant pleural mesothelioma.

Contributors from ADDRI: A/Professor Anthony Linton A/Professor Steven Kao

Reference:

Williams M, Kirschner MB, Cheng YY, Hanh J, Weiss J, Mugridge N, Wright CM, Linton A, Kao SC, Edelman JJ, Vallely MP, McCaughan BC, Cooper W, Klebe S, Lin RC, Brahmbhatt H, MacDiarmid J, van Zandwijk N, Reid G. miR-193a-3p is a potential tumor suppressor in malignant pleural mesothelioma. Oncotarget. 2015; 6(27): 23480-95.

2014

Pomegranate Extracts Impact the Androgen Biosynthesis Pathway in Prostate Cancer Models in vitro and in vivo

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Ming DS, Pham S, Adomat H, Deb S, Hosseini-Beheshti E, Chin MY, Locke J, Guns(Tomlinson) ES. Pomegranate Extracts Impact the Androgen Biosynthesis Pathway in Prostate Cancer Models in vitro and in vivo. J Steroid Biochem Mol Biol. 2014 Feb 22;143C:19-28. (IF=4.29)

Reproducibility and efficiency of serum-derived exosome extraction methods

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Caradec J, Kharmate G, Hosseini-Beheshti E, Guns (Tomlinson) ES. Reproducibility and efficiency of serum-derived exosome extraction methods. Clin Biochem. 2014 Sep;47(13-14):1286-92. (IF=3.28)

Next-Generation Steroidogenesis Inhibitors, Dutasteride and Abiraterone, Attenuate but Still Do Not Eliminate Androgen Biosynthesis in 22RV1 Cells in vitro

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Pham S, Deb S, Ming DS, Adomat H, Hosseini-Beheshti E, Zoubeidi A, Gleave M, Tomlinson Guns ES. Next-Generation Steroidogenesis Inhibitors, Dutasteride and Abiraterone, Attenuate but Still Do Not Eliminate Androgen Biosynthesis in 22RV1 Cells in vitro. J Steroid Biochem Mol Biol. 2014 Oct;144 Pt B:436-44. (IF=4.29)

An RNAi-based screen reveals PLK1, CDK1 and NDC80 as potential therapeutic targets in malignant pleural mesothelioma

Contributors from ADDRI: A/Professor Anthony Linton A/Professor Steven Kao

Reference:

Linton A, Cheng YY, Griggs K, Kirschner M, Gattani S, Srikaran S, Kao SC, McCaughan B, Klebe S, van Zandwijk N, and Reid G. An RNAi-based screen reveals PLK1, CDK1 and NDC80 as potential therapeutic targets in malignant pleural mesothelioma. British Journal of Cancer. 2014 Jan 21;110(2):510-9.

Factors associated with survival in a large series of patients with malignant pleural mesothelioma in New South Wales

Contributors from ADDRI: A/Professor Anthony Linton A/Professor Steven Kao

Reference:

Linton A, Pavlakis N, Kao SC, Clarke S, Vardy J, van Zandwijk N. Factors associated with survival in a large series of patients with malignant pleural mesothelioma in New South Wales. British Journal of Cancer 2014 ; 111(9): 1860-9.

2013

Differing association of macrophage subsets with atherosclerotic plaque stability

Contributors from ADDRI: Dr Virginia James

Reference:

H.J. Medbury, V. James, J. Ngo, K. Hitos, Y. Wang, D.C Harris, J.P Fletcher. ▪ Differing association of macrophage subsets with atherosclerotic plaque stability. International Angiology 2013.

Immunohistochemistry in the diagnosis of malignant pleural mesothelioma: Trends in Australia and a literature review

Contributors from ADDRI: A/Professor Anthony Linton A/Professor Steven Kao

Reference:

Linton A, Kao S, Vardy J, Clarke S, van Zandwijk N, Klebe S. Immunohistochemistry in the diagnosis of malignant pleural mesothelioma: Trends in Australia and a literature review. Asia Pac J Clin Oncol. 2013 Sep;9(3):273-9.

Glasgow Prognostic Score As a Prognostic Factor in Metastatic Castration-Resistant Prostate Cancer Treated With Docetaxel- Based Chemotherapy

Contributors from ADDRI: A/Professor Anthony Linton

Reference:

Linton A, Pond G, Clarke S, Vardy J, Galsky M, Sonpavde G. Glasgow Prognostic Score As a Prognostic Factor in Metastatic Castration-Resistant Prostate Cancer Treated With Docetaxel- Based Chemotherapy. Clin Genitourin Cancer. 2013 Dec;11(4):423-30

2012

Characterization of Antioxidant Capacity from Fruits with Distinct Anthocyanin Biosynthetic Pathways

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Hosseini-Beheshti E, Lund ST. and Kitts DD. Characterization of Antioxidant Capacity from Fruits with Distinct Anthocyanin Biosynthetic Pathways. J Nutr and Food Sci. 2012, 2:122. (IF=3.48)

Exosomes as Biomarker Enriched Microvesicles: Characterization of Exosomal Proteins derived from a Panel of Prostate Cell Lines with Distinct AR Phenotypes

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Hosseini-Beheshti E, Pham S., Adomat H., Li N, Guns (Tomlinson) ES. Exosomes as Biomarker Enriched Microvesicles: Characterization of Exosomal Proteins derived from a Panel of Prostate Cell Lines with Distinct AR Phenotypes. Mol Cell Proteomics. 2012 Oct;11(10):863-85. ** (IF=7.25)

The ticking time-bomb of asbestos: Its insidious role in the development of malignant mesothelioma

Contributors from ADDRI: A/Professor Anthony Linton

Reference:

Linton A, Vardy J, Clarke S, van Zandwijk N. The ticking time-bomb of asbestos: Its insidious role in the development of malignant mesothelioma. Critical Reviews in Oncology/Hematology. 2012: 84 (2): 200-212.

Inflammation in malignant mesothelioma friend or foe?

Contributors from ADDRI: A/Professor Anthony Linton A/Professor Steven Kao

Reference:

Linton A, van Zandwijk N, Reid G, Clarke S, Kao S. Inflammation in malignant mesothelioma friend or foe? Ann Cardiothorac Surg 2012: 1(4):516-522.

Radical surgery for malignant pleural mesothelioma: have we identified the appropriate selection tools?

Contributors from ADDRI: A/Professor Anthony Linton A/Professor Steven Kao

Reference:

van Zandwijk N, Reid G, Linton A, Kao S. Radical surgery for malignant pleural mesothelioma: have we identified the appropriate selection tools? Ann Cardiothorac Surg. 2012 Nov;1(4):481-6.

2009

Comparison of Antioxidant Activity of Two Soft Fruits Sources with Different Anthocyanin Composition

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Hosseini-Beheshti E, Lund, ST. and Kitts, DD. 2009. Comparison of Antioxidant Activity of Two Soft Fruits Sources with Different Anthocyanin Composition. Acta Hort. 2009. (ISHS) 841:519-522.

Testicular Cancer

Contributors from ADDRI: A/Professor Anthony Linton

Reference:

Linton A, Grimison P. Testicular Cancer. Australian Doctor: How to Treat. 2009. 17 June. 33-40

2008

Acute Dexamethasone-induced Increase in Cardiac Lipoprotein Lipase Requires Activation of Both Akt and Stress Kinases

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Kewalramani G, Puthanveetil P, Kim MS, Wang F, Lee V, Hau N, Beheshti E, Ng N, Abrahani A, Rodrigues B. Acute Dexamethasone-induced Increase in Cardiac Lipoprotein Lipase Requires Activation of Both Akt and Stress Kinases. Am J Physiol Endocrinol Metab. 2008 Jul;295(1):E137-47. (IF=4.31)

Protein kinase D is a Key Regulator of Cardiomyocyte Lipoprotein Lipase Secretion after Diabetes

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Kim MS, Wang F, Puthanveetil P, Kewalramani G, Hosseini-Beheshti E, Ng N, Wang Y, Kumar U, Innis S, Proud CG, Abrahani A, Rodrigues B. Protein kinase D is a Key Regulator of Cardiomyocyte Lipoprotein Lipase Secretion after Diabetes. Circ Res. 2008 Aug 1;103(3):252-60. (IF=17.37)

Cardiac Glycogen Accumulation Following Dexamethasone is Regulated by AMPK

Contributors from ADDRI: Dr Elham Hosseini Beheshti

Reference:

Puthanveetil P, Wang F, Kewalramani G, Kim MS, Hosseini-Beheshti E, Ng N, Lau W, Pulinilkunnil T, Allard MF, Abrahani A, Rodrigues B. Cardiac Glycogen Accumulation Following Dexamethasone is Regulated by AMPK. Am J Physiol Heart Circ Physiol. 2008 Oct; 295(4):H1753-62. (IF=4.73)

Who is ADDRI?

<img class="alignnone wp-image-1115 size-large" src="https://addri.org.au/wp-content/uploads/2024/02/ADRI28-07-23CTimPascoePhoto0401-1024x683.jpg" alt="" width="1024" height="683" data-eio="l" />

Our team

<img class="alignnone wp-image-1110 size-large" src="https://addri.org.au/wp-content/uploads/2024/02/ADRI28-07-23CTimPascoePhoto0367-1024x683.jpg" alt="" width="1024" height="683" data-eio="l" />

The importance of collaboration

About the Diseases

<img class="alignnone wp-image-1109 size-large" src="https://addri.org.au/wp-content/uploads/2024/02/ADRI28-07-23CTimPascoePhoto0363-1024x683.jpg" alt="" width="1024" height="683" data-eio="l" />

What is asbestos?

<img class="alignnone wp-image-1111 size-large" src="https://addri.org.au/wp-content/uploads/2024/02/ADRI28-07-23CTimPascoePhoto0368-1024x683.jpg" alt="" width="1024" height="683" data-eio="l" />

What is Silica?

Research

<img class="alignnone wp-image-1113 size-large" src="https://addri.org.au/wp-content/uploads/2024/02/ADRI28-07-23CTimPascoePhoto0388-1024x683.jpg" alt="" width="1024" height="683" data-eio="l" />

Our impact

<img class="alignnone size-large wp-image-1175" src="https://addri.org.au/wp-content/uploads/2024/02/Working-globally-image-scaled-e1708405412670-1024x679.jpg" alt="" width="1024" height="679" data-eio="l" />

Working globally

Support

<img class="alignnone wp-image-1120 size-full" src="https://addri.org.au/wp-content/uploads/2024/02/Ms-Jocelyn-McLean-Mesothelioma-Support-Coordinator.jpg" alt="" width="600" height="400" data-eio="l" />

Mesothelioma support

<img class="alignnone size-large wp-image-2029" src="https://addri.org.au/wp-content/uploads/2024/04/JennyColes-1-683x1024.jpg" alt="" width="683" height="1024" data-eio="l" />

Silicosis support

Education

eToolkit

<img class="alignnone size-large wp-image-1266" src="https://addri.org.au/wp-content/uploads/2024/03/Nepean-Cancer-Care-Centre-1024x768.jpg" alt="" width="1024" height="768" data-eio="l" />

Mesothelioma learning module

Publications

Research Menu

Publications

2024

Repotrectinib in ROS1 Fusion-Positive Non-Small-Cell Lung Cancer

Variations in patterns of prescribing durvalumab in stage III lung cancer: a survey of Australian Medical Oncologists

First-line chemoimmunotherapy and immunotherapy in patients with non-small cell lung cancer and brain metastases: a registry study

Lurbinectedin in small cell lung cancer: real-world experience of a multicentre national early access programme

Patient satisfaction with telehealth consultations in medical oncology clinics: A cross-sectional study at a metropolitan centre during the COVID-19 pandemic

Influence of EGFR mutation status and PD-L1 expression in stage III unresectable non-small cell lung cancer treated with chemoradiation and consolidation durvalumab

A Phase II trial of alternating osimertinib and gefitinib therapy in advanced EGFR-T790M positive non-small cell lung cancer: OSCILLATE

Successful Osimertinib Rechallenge After Relapse Following Adjuvant Osimertinib: A Case Report

Hemophagocytic lymphohistiocytosis (HLH) and cytokine release syndrome (CRS) in a patient with oncogene-addicted metastatic non-small cell lung cancer (NSCLC) following combination chemotherapy-immunotherapy

Brief Report: Real-World Toxicity and Survival of Combination Immunotherapy in Pleural Mesothelioma-RIOMeso

Alectinib in Resected ALK-Positive Non-Small-Cell Lung Cancer

Treatment selection and real-world analysis of immunotherapy with or without chemotherapy in PD-L1-high metastatic non-small cell lung cancer

Long-Term Safety and Efficacy of Transcatheter Microwave and Radiofrequency Denervation in a Chronic Ovine Model

A novel dye-sensitised solar cell based portable sensor for chemical detection

Engineered extracellular vesicles expressing ICAM-1: A promising targeted delivery system for T cell modifications

Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches

Real world efficacy and toxicity of consolidation durvalumab following chemoradiotherapy in older Australian patients with unresectable stage III non-small cell lung cancer

2023

LOREALAUS: LOrlatinib REAL-World AUStralian Experience in Advanced ALK-Rearranged NSCLC

Accurate isolation and detection of circulating tumor cells using enrichment-free multiparametric high resolution imaging

Leptospermum extract (QV0) suppresses pleural mesothelioma tumor growth in vitro and in vivo by mitochondrial dysfunction associated apoptosis

AdvanTIG-105: a phase I dose escalation study of the anti-TIGIT monoclonal antibody ociperlimab in combination with tislelizumab in patients with advanced solid tumors

PEMMELA: a promising regimen at the expense of toxicity

A tailored approach to horizon scanning for cancer medicines

Re-re-biopsy? How much tumor is enough in the era of precision oncology?

HERTHENA-Lung01, a Phase II Trial of Patritumab Deruxtecan (HER3-DXd) in Epidermal Growth Factor Receptor-Mutated Non-Small-Cell Lung Cancer After Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Therapy and Platinum-Based Chemotherapy

Skin 11β-hydroxysteroid dehydrogenase type 1 enzyme expression regulates burn wound healing and can be targeted to modify scar characteristics

Advanced pathophysiology mimicking lung models for accelerated drug discovery

A structural analysis of the nsp9 protein from the coronavirus MERS CoV reveals a conserved RNA binding interface

Extracellular vesicles from biological fluids as potential markers in castration resistant prostate cancer

ImmunoInertial microfluidics: A novel strategy for isolation of small EV subpopulations

Small and large extracellular vesicles derived from pleural mesothelioma cell lines offer biomarker potential

Immunomodulatory potential of human clonal mesenchymal stem cells and their extracellular vesicle subpopulations in an inflammatory-mediated diabetic Rhesus monkey model

Lidocaine for Neuropathic Cancer Pain (LiCPain): study protocol for a mixed methods pilot study

High mesothelin expression by immunohistochemistry predicts improved survival in pleural mesothelioma

2022

An update on emerging therapeutic options for malignant pleural mesothelioma

The emerging role of the lung microbiome and its importance in non-small cell lung cancer diagnosis and treatment

Corrigendum to “The emerging role of the lung microbiome and its importance in non-small cell lung cancer diagnosis and treatment” [Lung Cancer 165C (2022) 124-132]

Pembrolizumab for previously treated advanced anal squamous cell carcinoma: results from the non-randomised, multicohort, multicentre, phase 2 KEYNOTE-158 study

Dying of mesothelioma: A qualitative exploration of caregiver experiences

Asbestos-related lung cancer: Clinical characteristics and survival outcomes in an Australian cohort seeking workers compensation

A case of steroid responsive nivolumab induced cholangitis

Elevated neutrophil-to-lymphocyte ratio (NLR) is associated with poorer progression-free survival in unresectable stage III NSCLC treated with consolidation durvalumab

A multi-center real-world experience of IMpower150 in oncogene driven tumors and CNS metastases

Squamous cell carcinoma differentiation at progression as a resistance mechanism in metastatic non-small cell lung carcinoma harbouring a targetable mutation

Exploring MicroRNA and exosome involvement in malignant pleural mesothelioma drug response

Controlled dual release of dihydrotestosterone and flutamide from polycaprolactone (PCL) electrospun scaffold accelerates burn wound healing

Exploring the role of extracellular vesicles and their protein cargo in lung cancer metastasis: a review

Chloroquine treatment induces secretion of autophagy-related proteins and inclusion of Atg8-family proteins in distinct extracellular vesicle populations

Extracellular Vesicles: Interplay with the Extracellular Matrix and Modulated Cell Responses

Bacterial extracellular vesicles and their novel applications in health